The Functional Liver Detoxification Profile (FLDP) challenges the liver’s Phase I and Phase II detoxification capacity with low doses of Caffeine, Aspirin and Paracetamol. Saliva and urine specimens, collected at timed intervals, are then analysed for metabolites of the three compounds to determine the efficiency of the liver in their conversion and clearance from the body.
Phase I reactions utilise the Cytochrome P450 mixed function oxidase (MFO) enzymes. The primary function of these enzymes is to oxidise endogenous and exogenous chemicals for excretion. This provides a mechanism of protection from a wide variety of toxins.
Phase I is followed by an intermediate phase where oxygen-free radicals may be generated in substantial quantities, which in some instances may change harmless compounds into potentially toxic substances.
Phase II reactions involve the addition of a small polar molecule to the substance, a conjugation step that may or may not be preceded by Phase I. Several types of conjugation reactions occur in the body, including glutathionation, sulphation, glucuronidation, glycination.
The results of an FLDP will support accurate identification of the individual’s detoxification profile and assist in the direction of treatment. The FLDP may particularly provide valuable information in the management of patients who suffer from food allergies, multiple chemical sensitivities, chronic fatigue syndrome, “leaky gut” and hormonal imbalance eg. premenstrual syndrome and menopausal symptoms.
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